Modifying Cellular Senescence to Treat Age-Related Diseases


Age may bring a series of degenerative changes which cause illness, ultimately resulting in death. The cause of many of these degenerative changes can be attributed to cells entering a state of senescence and the accompanying senescent associated secretory phenotype. Previous research has looked into how to remove senescent cells and their ramifications. However, cellular senescence also carries beneficial properties, such as tumor suppression, and can be useful for cancer treatment. Therefore, complete removal of senescence is not a rational approach to treating age-related diseases and other approaches must be investigated. This paper reviews literature regarding relevant developments in modifying cellular senescence so as to answer the research question "How can modification of cellular senescence delay aging by treating age-related diseases?". Recent research on suppressing and inducing senescence to benefit health are explored. Furthermore, the feasible applications of methods senescence alteration to treat age-related diseases are discussed. The results of this paper conclude that aging, in essence, cannot be reversed or cured. However, with the modification of cellular senescence, prevention of age-related diseases, as well as their treatment is attainable. To this degree, aging is interpreted as having been delayed along with healthy aging being feasible. This paper explores novel advancements within the field of senescence alteration to add to existing literature, as well as give a new perspective on the debate surrounding the treatment of aging.


Original Research



Publication date

July 2019


178 - 185