Peanut Allergies: Experimental Immunotherapy and the Translation to Clinical Practice

Abstract

FDA approved treatments for food allergies are scarce. This article investigates the experimental immunotherapy realm, especially in relation to peanut allergies, and provides an overviewof the potential of each type of experimental treatment with a specific focus on the translation to clinical practice. Sublingual and oral immunotherapy are analyzed, as well as probiotic and helminth-related treatments, anti IgE-related treatments, cytokine related-treatments, experimental vaccine-related treatments, modified protein related treatments and possible filaggrin related-treatments. All treatments are currently experimental but illuminate great potential. Each treatment also exhibits experimental flaws that should still be overcome before a translation from "bench to bedside" can be made. The experimental realm is, nevertheless, promising, innovative and rapidly expanding.

Type

Review

Volume(issue)

2(1)

Publication date

October 2017

Pages

99 - 104

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