Despite technological developments in diagnosis and treatment options, glioblastoma multiforme (GBM) remains the most aggressive and diffcult to treat malignant brain tumor that is associated with a high prevalence as well as a high mortality rate. More efficient therapeutic strategies that could overcome the inability to properly treat GBM tumors are needed. Hyperthermia is well-studied procedure that exposes tumor cells to a local temperature increase that results into changes in cellular structures and even cell apoptosis. However, hyperthermia in the treatment of glioblastoma has not yet been established in clinical practice due to physical limitations and toxicity. Quite recently, advances have been made in the application of magnetic nanoparticles (MNPs) that induce hyperthermia offer an attractive approach. This mini-review first addresses current challenges in the treatment of GBM and then focuses on the molecular dynamics behind hyperthermia. It also summarizes physical properties of MNPs and their role in thermotherapy. The review further highlights some exciting examples of studies that used this novel approach in the treatment of GBM.